Strange discussion. As far as I know there are several different keyboard layouts that do not match the “default typewriter” one.
That you are sitting in front of a QWERT* keyboard is more the result that you did not care at the time you bought it.
There are even so called “ergonomic keyboards”. If they are? I do not know.
The drawback of virtual keyboards is that they do not “feel” like a keyboard. You need to hammer on a hard surface without feeling it does anything. On a physical keyboard you would feel the touch, the move and the resistance of the keys. The difference is the haptic perception.
[Yes, I know there are physical keyboards with real bad haptic like the old foliage keyboards (I do not know if they have a name), or with to much haptic like the keyboards with this annoying click sound]
Typically each keyboard has a limited number of keys. So it can easily happen that not all keys you need fit at the same time. That is the reason for the layout changer or function keys (caps, alt, alt gr, fn) that toggle from one layout to another while holding this key. I do not see a problem in that. You just need to know what the other layout is when you activate that mode.
There are some other techniques that look for a sequence. E.g. I have a <´> key. When I press it nothing happens, but the next character key will result in an accent. This even works with layout changer on both keys
e.g.
<´>,<a>
-> á
<shift + ´>,<a>
-> à
<`>,<shift + a>
-> Á
<shift `>,<shift + a>
-> À
The things I frequently see at laptops is that each laptop manufacturer tries to invent his own keyboards layouts especially where the layout changer e.g. <fn> is. I even had a laptop that exchanged <ctrl> with <fn>, which was a bit disturbing. I saw laptops where the <cr> key was hard to hit. But in most cases the keyboards typical keys are at the known location (if these keys exist at all).
I think currently the virtual keyboards are on the run, because of the touch displays. A lot of people recognize they are not the best for daily business (when you need to fluently type a lot). I guess they will survive, but there will be not much change to them.
Maybe something really revolutionary will be invented getting its own part in the world of input devices. Maybe we already have it, but it is not established as such (I think of voice recognition, handwriting, gesture, lip reading, body language…).